Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

@article{Peiser2011AllergicCD,
  title={Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects},
  author={Matthias Peiser and Tewes Tralau and J Heidler and Anne Marie Api and Josje H. E. Arts and David A Basketter and John English and Thomas L. Diepgen and Robert C. Fuhlbrigge and Anthony A. Gaspari and Jeanne Duus Johansen and Ann-Therese Karlberg and Ian Kimber and Jean-Pierre Lepoittevin and Manfred Liebsch and Howard I Maibach and S. F. Martin and H F Merk and Thomas Platzek and Thomas Rustemeyer and Axel Schnuch and Rob J. Vandebriel and Ian R. White and Andreas Luch},
  journal={Cellular and Molecular Life Sciences},
  year={2011},
  volume={69},
  pages={763 - 781}
}
Contact allergies are complex diseases, and one of the important challenges for public health and immunology. The German ‘Federal Institute for Risk Assessment’ hosted an ‘International Workshop on Contact Dermatitis’. The scope of the workshop was to discuss new discoveries and developments in the field of contact dermatitis. This included the epidemiology and molecular biology of contact allergy, as well as the development of new in vitro methods. Furthermore, it considered regulatory aspects… Expand
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References

SHOWING 1-10 OF 245 REFERENCES
Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers.
TLDR
This perspective focuses on two areas that have yielded new useful information during the last 20 years: structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. Expand
Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment.
TLDR
Three non-animal test methods have been evaluated in Colipa interlaboratory ring trials for their potential to predict skin sensitisation potential and were recently submitted to ECVAM for formal pre-validation. Expand
Allergic Contact Dermatitis
TLDR
This article seeks to consider skin sensitization and ACD in holistic fashion, bridging experimental observations with clinical disease and basic mechanisms with practical toxicology. Expand
Development of a peptide reactivity assay for screening contact allergens.
TLDR
The data presented show that measuring peptide reactivity has utility for screening chemicals for their skin sensitization potency and thus potential for reducing the authors' reliance on animal test methods. Expand
Genetics and Individual Predispositions in Contact Dermatitis
TLDR
The endogenous aspects of contact dermatitis and genetics and predisposition related to certain phenotypes are the focus of this chapter. Expand
Effector and regulatory mechanisms in allergic contact dermatitis
TLDR
ACD should be considered as a breakdown of the skin immune tolerance to haptens, and the nature, the mode and the site of action of the regulatory T cells that control the skin inflammation are addressed with the aim of developing new strategies of tolerance induction in allergic patients. Expand
Chemical-Induced Contact Hypersensitivity in the Mouse Model
TLDR
Great efforts are being made to develop reliable in vitro assay systems for predictive risk assessment for hypersensitivity reactions, and recent findings in this field using the mouse contact hypersensitivity model will be discussed here. Expand
Allergic Contact Dermatitis and Atopic Eczema
TLDR
Clinical findings reported to date are outlined and the basic mechanism of allergic contact dermatitis (ACD) in relation to relevant pathogenetic characteristics of AE is reviewed, possibly interfering with the pathogenesis of ACD. Expand
Contact allergy epidemics and their controls *
TLDR
The aim of this review is to present the published knowledge on 6 historical epidemics of contact allergy to apply this knowledge on the prevention and control of future contact allergy epidemics. Expand
Understanding fragrance allergy using an exposure‐based risk assessment approach
TLDR
By estimating the exposure to the allergen and its allergenic potency, it is feasible to assess quantitatively the sensitization risk of an ingredient in a particular product type. Expand
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