Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.

Abstract

Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic… (More)
DOI: 10.1126/scitranslmed.aag1370

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Cite this paper

@article{Cho2016AllergicAI, title={Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.}, author={Josalyn L. Cho and Morris F. Ling and David C. Adams and Lucas Faustino and Sabina A. Islam and R Malekpour Afshar and Jason W. Griffith and Robert S. Harris and Aylwin Ng and Giorgia Radicioni and Amina A. Ford and Andre K Han and Ramnik J. Xavier and William W Kwok and Richard C. Boucher and James J Moon and Daniel L. Hamilos and Mehmet Kesimer and Melissa J. Suter and Benjamin D. Medoff and Andrew D Luster}, journal={Science translational medicine}, year={2016}, volume={8 359}, pages={359ra132} }