Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells.

@article{Jin2009AllergicAH,
  title={Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells.},
  author={Niyun Jin and Christina L. Roark and Nobuaki Miyahara and Christian Taube and M. Kemal Aydintug and J. M. Wands and Yafei Huang and Y Hahn and Erwin W. Gelfand and Rebecca L O'brien and Willi K. Born},
  journal={Journal of immunology},
  year={2009},
  volume={182 4},
  pages={2002-10}
}
Allergic airway hyperresponsiveness (AHR) in OVA-sensitized and challenged mice, mediated by allergen-specific Th2 cells and Th2-like invariant NKT (iNKT) cells, develops under the influence of enhancing and inhibitory gammadelta T cells. The AHR-enhancing cells belong to the Vgamma1(+) gammadelta T cell subset, cells that are capable of increasing IL-5 and IL-13 levels in the airways in a manner like Th2 cells. They also synergize with iNKT cells in mediating AHR. However, unlike Th2 cells… CONTINUE READING

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toward Th 2

  • P. M. Hansbro, P. S. Foster
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