Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment.

@article{Acevedo2011AllergenicityOA,
  title={Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment.},
  author={Nathalie Acevedo and Anja Erler and Peter Briza and Franca Puccio and F{\'a}tima Ferreira and Luis Caraballo},
  journal={International archives of allergy and immunology},
  year={2011},
  volume={154 3},
  pages={195-206}
}
BACKGROUND Ascaris lumbricoides induces a Th2 response and specific IgE synthesis in humans. This confers antiparasite immunity but could modify the natural history of allergic diseases in the tropics, justifying the study of its allergenic composition. We analyzed the allergenic properties of Ascaris tropomyosin and the frequency of sensitization in subjects exposed to the parasite. METHODS cDNA was obtained by reverse transcription PCR, cloned into pQE30-UA and purified as a 6× His-tagged… CONTINUE READING
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