Allergenicity and antigenicity of wild-type and mutant, monomeric, and dimeric carrot major allergen Dau c 1: destruction of conformation, not oligomerization, is the roadmap to save allergen vaccines.

BACKGROUND Carrot allergy is caused by primary sensitization to birch pollen. Continuous carrot exposure results in additional Dau c 1-specific allergic responses. Thus, immunotherapy with birch pollen may not improve the food allergy. OBJECTIVE Evaluation of mutation and oligomerization of the major carrot allergen, Dau c 1, in regard to alteration of… CONTINUE READING