Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.

@article{Hansen1999AllergenspecificTC,
  title={Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.},
  author={G. Lokken Hansen and Gerald T Berry and Rosemarie H. Dekruyff and Dale T. Umetsu},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 2},
  pages={175-83}
}
Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5. Because Th1 cells antagonize Th2 cell functions, it has been proposed that immune deviation toward Th1 can protect against asthma and allergies. Using an adoptive transfer system, we assessed the roles of Th1, Th2, and Th0 cells in a mouse model of asthma… CONTINUE READING

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