Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis.

@article{Saito2001AllergeninducedMU,
  title={Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis.},
  author={Hiroko Saito and Karen Howie and Jennifer Wattie and Avram E. Denburg and Russ Ellis and Mark D. Inman and Judah A. Denburg},
  journal={Immunology},
  year={2001},
  volume={104 2},
  pages={226-34}
}
The role of inflammatory effector cells in the pathogenesis of airway allergy has been the subject of much investigation. However, whether systemic factors are involved in the development of local responses in both upper and lower airways has not been fully clarified. The present study was performed to investigate aspects of the pathogenesis of isolated allergic rhinitis in a murine model sensitized to ovalbumin (OVA). Both upper- and lower-airway physiological responsiveness and inflammatory… CONTINUE READING