Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model.

@article{Vissers2004AllergenII,
  title={Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model.},
  author={Joost L. M. Vissers and Betty C. A. M. van Esch and Gerard A. Hofman and Martien L. Kapsenberg and Frank R Weller and Antoon J M van Oosterhout},
  journal={The Journal of allergy and clinical immunology},
  year={2004},
  volume={113 6},
  pages={1204-10}
}
BACKGROUND Human studies have demonstrated that allergen immunotherapy induces memory suppressive responses and IL-10 production by allergen-specific T cells. Previously, we established a mouse model in which allergen immunotherapy was effective in the suppression of allergen-induced asthma manifestations. OBJECTIVE In this study, we examined whether immunotherapy induces a long-lasting effect and investigated the role of IL-10 in successful immunotherapy. METHODS Ovalbumin-sensitized BALB… CONTINUE READING