Allergen cleavage by effector cell-derived proteases regulates allergic inflammation.

  title={Allergen cleavage by effector cell-derived proteases regulates allergic inflammation.},
  author={Ingrid Rauter and M Krauth and Sabine Flicker and Anna Gieras and Kerstin Westritschnig and Susanne Vrtala and Nadja Balic and Susanne Spitzauer and Johannes Huss-Marp and K Brockow and Ulf Darsow and Johannes Hofaker Ring and Heidrun Behrendt and Hans Semper and Peter Valent and Rudolf Valenta},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 7},
The key event of allergic inflammation, allergen-induced crosslinking of mast cell-bound IgE antibodies, is accompanied by release of inflammatory mediators, cytokines, and proteases, in particular beta-tryptase. We provide evidence that protease-mediated cleavage of allergens represents a mechanism that regulates allergen-induced mast cell activation. When used in molar ratios as they occur in vivo, purified beta-tryptase cleaved major grass and birch pollen allergens, resulting in defined… CONTINUE READING

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