Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro

@article{Yum2010AllergenInducedCO,
  title={Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro},
  author={Hye Young Yum and Jae Youn Cho and M. Miller and D. Broide},
  journal={International Archives of Allergy and Immunology},
  year={2010},
  volume={155},
  pages={12 - 22}
}
  • Hye Young Yum, Jae Youn Cho, +1 author D. Broide
  • Published 2010
  • Biology, Medicine
  • International Archives of Allergy and Immunology
  • Background: Basic fibroblast growth factor (bFGF) is a cytokine that is mitogenic for fibroblasts and smooth muscle and may play a role in airway remodeling in asthma. We have used a mouse model of chronic ovalbumin (OVA) allergen-induced airway remodeling to determine whether bFGF and fibroblast growth factor receptor-1 are expressed and regulated by corticosteroids in the airway, as well as to determine whether bFGF mediates expression of another proremodeling cytokine, transforming growth… CONTINUE READING
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