Allergen-Associated Immunomodulators: Modifying Allergy Outcome

  title={Allergen-Associated Immunomodulators: Modifying Allergy Outcome},
  author={Cristina G{\'o}mez-Casado and Araceli D{\'i}az‐Perales},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
The prevalence of allergies is increasing since mid twentieth century; however the underlying causes of this increase are not fully clear. Understanding the mechanism by which a harmless protein becomes an allergen provides us with the basis to prevent and treat these diseases. Although most studies on allergen immunogenicity have traditionally focused on structural properties of the proteins, it is increasingly clear that allergenicity cannot be determined only based on structural features of… 

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

An overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food- induced autoimmune diseases, such as celiac disease is provided.

Pollen Lipids Can Play a Role in Allergic Airway Inflammation

In seed plants, pollen grains carry the male gametes to female structures, and cause airway inflammation in one out of four persons in the population, which was traditionally attributed to soluble glycoproteins, leaking into the nasal mucosa or the conjunctiva.

Interaction of Non-Specific Lipid-Transfer Proteins With Plant-Derived Lipids and Its Impact on Allergic Sensitization

The current knowledge on diversity of lipid ligands of plant LTPs is summarized, recent studies performed with allergenic nsLTPs are illustrated to investigate the effect of lipid binding on the structural modification and IgE-binding properties of proteins, and the potential effect on the innate immune responses.

Innate Immune Responses in the Alternaria-Dendritic Cell Interaction

This study reveals that A. alternata components may balance the innate immune responses between Th2 and Th17 pathways, and/or contributes to the development and exacerbation of more serve neutrophilic forms of asthma.

Literature review in support of adjuvanticity/immunogenicity assessment of proteins

It is expected that the availability of new humanized animal models and the possibility to deploy artificial intelligent systems on the vastity of human data will become a general direction aiming to help answering specific questions relating to the immune systems, including the adjuvanticity and immunogenicity of food/feed proteins.

Assessment of antimicrobial phytopeptides: lipid transfer protein and hevein-like peptide in the prospect of structure, function and allergenic effect

The structures and various functions of lipid transfer protein and hevein-like peptide are discussed, which play a wide range of crucial function in plants, including regulation of stomata, ion channel, heavy metals and membrane fluidity.

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

An overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies is provided.

Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze.



Determinants of allergenicity.

Structural biology of allergens

Major allergens may have special aerobiological properties and allergenic structures that can enhance allergenicity via Toll-like receptor (TLR) or CD1 pathways and peptides as well as nonproteinaceous ligands.

The Role of Lipid Transfer Proteins in Allergic Diseases

Although Pru p 3 represents the predominant LTP in terms of patients’ IgE recognition, the contribution of pollen LTPs in primary sensitization cannot be ruled out andcule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy.

Do lipids influence the allergic sensitization process?

Allergens as Immunomodulatory Proteins: The Cat Dander Protein Fel d 1 Enhances TLR Activation by Lipid Ligands

It is proposed that Fel d 1 and Can f 6 belong to a group of allergen immunomodulatory proteins that enhance innate immune signaling and promote airway hypersensitivity reactions in diseases such as asthma.

Secretion of Proinflammatory Eicosanoid-Like Substances Precedes Allergen Release from Pollen Grains in the Initiation of Allergic Sensitization

The finding opens a new dimension of understanding of the early events in allergic sensitization, indicating that proinflammatory effects of the allergen carrier, e.g. the pollen grain itself, can lead to activation of the mucosal membrane.

Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project

This review is dedicated to summarizing current knowledge about the most important food allergen protein families and to presenting data from the EuroPrevallAllergen library, a proof-of-concept collection of highly purified, characterized and authenticated food allergens from animal and plant food sources to facilitate improved diagnosis of food allergies.

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

The results indicate that Der p 2 tends to be targeted by adaptive immune responses because of its auto-adjuvant properties, suggesting that intrinsic adjuvant activity by such proteins and their accompanying lipid cargo may have some generality as a mechanism underlying the phenomenon of allergenicity.

What establishes a protein as an allergen?

The Role of Protein Glycosylation in Allergy

  • F. Altmann
  • Biology
    International Archives of Allergy and Immunology
  • 2006
Low binding affinity between IgE and plant N-glycans now drops out as a plausible explanation for the benign nature of CCDs, which may result from blocking antibodies induced by an incidental ‘immune therapy’ exerted by everyday contact with plant materials.