Allelotype of pediatric rhabdomyosarcoma

@article{Visser1997AllelotypeOP,
  title={Allelotype of pediatric rhabdomyosarcoma},
  author={M Visser and Carin Sijmons and Johannes Bras and Robert J. Arceci and Marc B. Godfried and Linda J. Valentijn and Paul A. Vo{\^u}te and Frank Baas},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={1309-1314}
}
An allelotype covering all autosomes was constructed for the embryonal form of childhood rhabdomyosarcoma (ERMS) in order to identify regions encompassing tumorsuppressor genes (TSG) involved in ERMS. Thusfar most studies were focussed on chromosome 11p15.5, which frequently shows loss of heterozygozity (LOH) in embryonal tumors like RMS and Wilms' tumor (WT). In this study we show that, besides LOH of chromosome 11p15.5 (72%), LOH of chromosome 16q was present in 54% of the tumors analysed… 
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Despite similarities in the downstream targets of these genetic alterations, the striking cytogenetic and molecular differences between ARMS and ERMS indicate distinct molecular etiologies in these two subtypes.
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