Allelotype analysis of childhood acute lymphoblastic leukemia.

  title={Allelotype analysis of childhood acute lymphoblastic leukemia.},
  author={Seisho Takeuchi and C. R. Bartram and Masahiro Wada and A. Reiter and Yoshihiro Hatta and Taku Seriu and E E Lee and Carl W. Miller and Isao Miyoshi and H Phillip Koeffler},
  journal={Cancer research},
  volume={55 22},
To identify the genetic events that may play an important role in leukemogenesis of childhood ALL, we report for the first time the allelotyping of childhood ALL. Twenty-four cases of childhood ALL were screened for loss of heterozygosity (LOH) using 101 highly polymorphic microsatellite markers, which are distributed among all autosomal chromosomes. For LOH analysis on both chromosomes 9 and 12, 54 childhood ALL samples were examined. The most frequent allelic loss was found on chromosomal arm… CONTINUE READING


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