Allelic variation in TLR4 is linked to resistance to Salmonella Enteritidis infection in chickens.

@article{Li2017AllelicVI,
  title={Allelic variation in TLR4 is linked to resistance to Salmonella Enteritidis infection in chickens.},
  author={Peng Li and Huihua Wang and Xingwang Zhao and Zhongyong Gou and Ranran Liu and Yongmei Song and Qinghe Li and Mai-qing Zheng and Huanxian Cui and Nadia Everaert and Guiping Zhao and Jie Wen},
  journal={Poultry science},
  year={2017},
  volume={96 7},
  pages={2040-2048}
}
Salmonella Enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Polymorphisms of the TLR4 gene may affect recognition by Toll-like receptor 4 (TLR4) of bacterial lipopolysaccharide (LPS), leading to differences in host resistance to pathogenic infections. The present study has investigated polymorphic loci of chicken TLR4 (ChTLR4) in ten chicken breeds, electrostatic potentials of mutant structures of TLR4, and a linkage analysis between allelic… CONTINUE READING