Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.

@article{Frazier2013AllelicVI,
  title={Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.},
  author={William R. Frazier and Noriko K. Steiner and Li-hua Hou and Sivanesan Dakshanamurthy and C K Hurley},
  journal={Journal of immunology},
  year={2013},
  volume={190 12},
  pages={6198-208}
}
Although extensive homology exists between their extracellular domains, NK cell inhibitory receptors killer Ig-like receptor (KIR) 2DL2*001 and KIR2DL3*001 have previously been shown to differ substantially in their HLA-C binding avidity. To explore the largely uncharacterized impact of allelic diversity, the most common KIR2DL2/3 allelic products in… CONTINUE READING