Corpus ID: 37860406

Allelic variation in CRHR 1 predisposes to panic disorder by biasing towards fear

@inproceedings{Weber2015AllelicVI,
  title={Allelic variation in CRHR 1 predisposes to panic disorder by biasing towards fear},
  author={H. Weber and J. Richter and B. Straube and U. Lueken and K. Domschke and C. Schartner and B. Klauke and C. Baumann and C. Pan{\'e}-Farr{\'e} and C. Jacob and C. Scholz and P. Zwanzger and T. Lang and L. Fehm and A. Jansen and C. Konrad and T. Fydrich and A. Wittmann and B. Pfleiderer and A. Str{\"o}hle and A. Gerlach and G. Alpers and V. Arolt and P. Pauli and H. Wittchen and L. Kent and A. Hamm and T. Kircher and J. Deckert and A. Reif},
  year={2015}
}
Corticotropin releasing hormone (CRH) is a major regulator of the hypothalamicpituitary-adrenal (HPA) axis. Binding to its receptor CRHR1 triggers the downstream release of cortisol, a hormone needed for regulation of stress responses. Biochemical, behavioral and genetic studies revealed CRHR1 as a possible candidate gene for mood and anxiety disorders. Here, we aimed to evaluate CRHR1 as a candidate molecule in panic disorder (PD). Allelic variation throughout the CRHR1 gene was captured by 9… Expand
1 Citations

Figures and Tables from this paper

References

SHOWING 1-10 OF 68 REFERENCES
Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
  • M. Keck, N. Kern, +15 authors E. Binder
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder
  • L. M. Hodges, M. Weissman, +6 authors S. Hamilton
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
Neuropeptide S receptor gene — converging evidence for a role in panic disorder
Childhood maltreatment, the corticotropin‐releasing hormone receptor gene and adult depression in the general population
  • H. Grabe, C. Schwahn, +12 authors H. Völzke
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
...
1
2
3
4
5
...