Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia

@article{Smith2008AllelicVI,
  title={Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia},
  author={Robert C. Smith and Ronnen H. Segman and T Golcer-Dubner and Vera Pavlov and Bernard Lerer},
  journal={The Pharmacogenomics Journal},
  year={2008},
  volume={8},
  pages={228-236}
}
Schizophrenic patients who are treated with antipsychotics, especially second generation antipsychotics, such as clozapine and olanzapine, manifest an increase in cholesterol and triglycerides as well as other changes associated with diabetes or the metabolic syndrome. Previous studies have shown that polymorphisms in several genes that regulate lipid… CONTINUE READING