Allelic variation at the VHa locus in natural populations of rabbit (Oryctolagus cuniculus, L.).

@article{Esteves2004AllelicVA,
  title={Allelic variation at the VHa locus in natural populations of rabbit (Oryctolagus cuniculus, L.).},
  author={Pedro J Esteves and Dennis K Lanning and Nuno Ferrand and Katherine L. Knight and Shi-Kang Zhai and Wessel van der Loo},
  journal={Journal of immunology},
  year={2004},
  volume={172 2},
  pages={
          1044-53
        }
}
The large interallelic distances between the three rabbit Ig V(H)a lineages, a1, a2 and a3, suggest that the persistence time of the V(H)a polymorphism could amount to 50 million years, which is much longer than that of MHC polymorphisms. Rabbit originated in the Iberian Peninsula where two subspecies coexist, one of which is confined to Southwestern Iberia (Oryctolagus cuniculus algirus). We studied the V(H) loci in the original species range to obtain a better understanding of the… CONTINUE READING

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