Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations.

@article{RodrguezEsparragn2005AllelicVO,
  title={Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations.},
  author={Francisco Rodr{\'i}guez-Esparrag{\'o}n and Jos{\'e} Carlos Rodr{\'i}guez-P{\'e}rez and Yarid{\'e} Hern{\'a}ndez-Trujillo and Antonio Mac{\'i}as-Reyes and Alfonso Rodr{\'i}guez Medina and Araceli Caballero and Carlos Maria Ferrario},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 4},
  pages={
          854-60
        }
}
OBJECTIVE The antioxidant properties of high-density lipoprotein (HDL) have been attributed to paraoxonase (PON) enzyme activity. Human scavenger receptor class B type 1 (SR-BI; CD36 and lysosomal integral membrane protein-II analogous-1 [CLA-1]) plays a central role in HDL-mediated native and oxidized cholesteryl ester uptake. We tested for a significant contribution of common variant of these genes to coronary heart disease (CHD) risk and hypothesized that genetic-mediated PON activity and… CONTINUE READING

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