Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants.

@article{Visser2005AllelicVO,
  title={Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants.},
  author={Loes E. Visser and Ron H. N. van Schaik and Martin van Vliet and Paul H. Trienekens and Peter A.G.M. De Smet and Arnold G. Vulto and Albert Hofman and Cornelia M van Duijn and Bruno H. Ch. Stricker},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={77 6},
  pages={
          479-85
        }
}
INTRODUCTION Cytochrome P450 (CYP) plays a key role in the metabolism of coumarin anticoagulants and nonsteroidal anti-inflammatory drugs (NSAIDs). Because CYP2C9 is a genetically polymorphic enzyme, genetic variability could play an important role in the potential interaction between NSAIDs and coumarins. We investigated whether NSAIDs were associated with overanticoagulation during therapy with coumarins and evaluated the effect of the CYP2C9 polymorphisms on this potential interaction… CONTINUE READING
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