Allelic variants of CD40 and CD40L genes interact to promote antibiotic‐induced cutaneous allergic reactions

@article{Kim2009AllelicVO,
  title={Allelic variants of CD40 and CD40L genes interact to promote antibiotic‐induced cutaneous allergic reactions},
  author={Saeyoon Kim and J.-E. Lee and Sang-Hoon Kim and Y K Jee and Y.‐K. Kim and H-S Park and Kyung-up Min and H.‐W. Park},
  journal={Clinical \& Experimental Allergy},
  year={2009},
  volume={39}
}
Background The danger hypothesis provides a new perspective of the mechanisms underlying drug allergy. In this study, we evaluated associations between variations in the genes involved in danger signal pathways and antibiotic‐induced cutaneous allergic reactions (AICARs). 
Immunogenetics of allergic reactions to drugs
TLDR
An up -to -date review of drug allergy immunogenetics according to the probable physiopathological mechanisms is presented.
The complexity of T cell–mediated penicillin hypersensitivity reactions
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The need for a more comprehensive understanding of the underlying genetic and molecular basis of penicillin‐induced DHRs is highlighted, discussing the nature of the lesional T cells, the characterization of drug‐responsive T cells isolated from patient blood, and the potential mechanisms by which penicillins enter the antigen processing and presentation pathway to stimulate these deleterious responses.
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The most commonly reported genetic variants associated with DHRs are located in human leukocyte antigen genes and genes involved in drug metabolism pathways.
Genetic and ethnic risk factors associated with drug hypersensitivity
Purpose of reviewThe purpose of this article is to review the recent findings of studies reporting on the genetic and ethnic factors associated with hypersensitivity reactions to common drugs such as
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The findings suggest that the CD40 -1C/T SNP is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
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The findings suggest that the CD40 -1C/T SNP is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
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Canine progenitor epidermal keratinocytes express various inflammatory markers, including interleukin-8 and CD40, which are affected by certain antibiotics.
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Canine progenitor epidermal keratinocytes express various inflammatory proteins, with expression profiles being affected by certain antibiotics, and the potential pro-inflammatory effects of certain antibiotics in the skin are demonstrated.
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