Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians.

@article{Borgiani2007AllelicVI,
  title={Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians.},
  author={Paola Borgiani and Cinzia Ciccacci and Vittorio Forte and Silvia Romano and Giorgio Federici and Giuseppe Novelli},
  journal={Pharmacogenomics},
  year={2007},
  volume={8 11},
  pages={1545-50}
}
INTRODUCTION Warfarin is currently considered to be the anticoagulant of choice in the long-term treatment and prevention of thromboembolic events. However, it presents a narrow therapeutic range and a great interindividual dose variability. We investigated the influence of variants of the VKORC1 and CYP2C9 loci on the mean weekly warfarin dose (MWWD) required to reach stabilized therapeutic international normalized ratio, in order to confirm and to estimate the contribution of common genetic… CONTINUE READING

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