Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

@article{Salmon1992AllelicPO,
  title={Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.},
  author={Jane Salmon and Jeffrey C. Edberg and N L Brogle and Robert Kimberly},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={89 4},
  pages={
          1274-81
        }
}
  • Jane Salmon, Jeffrey C. Edberg, +1 author Robert Kimberly
  • Published in
    The Journal of clinical…
    1992
  • Biology, Medicine
  • Two different allelic polymorphisms among the isoforms of human Fc gamma receptors have been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma RIIA expressed on both PMN and monocytes and the NA1-NA2 polymorphism of the neutrophil Fc gamma RIII (huFc gamma RIIIB). To address the issues of whether the LR-HR polymorphism has a significant impact on Fc gamma R-mediated functions in human blood cells and whether any differences in LR-HR might be related to higher Fc… CONTINUE READING

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