Allelic polymorphisms in the FcgammaRIIC gene can influence its function on normal human natural killer cells.

@article{Ernst2002AllelicPI,
  title={Allelic polymorphisms in the FcgammaRIIC gene can influence its function on normal human natural killer cells.},
  author={Linda K. Ernst and Diana M Metes and Ronald B. Herberman and Penelope A. Morel},
  journal={Journal of molecular medicine},
  year={2002},
  volume={80 4},
  pages={
          248-57
        }
}
Natural killer (NK) cells are important in host defense against viruses and tumors and can induce death of virally infected cells following engagement of cell surface receptors. Human NK cells express receptors for the Fc portion of IgG which stimulate antibody-dependent cell-mediated cytotoxicity and induce cytokine production. We have shown that NK cells from certain individuals can express, in addition to CD16 (FcgammaRIIIa), isoforms of CD32 (FcgammaRIIc1-4). Expression of CD32 on NK cells… CONTINUE READING

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