Allelic polymorphism in the promoter (T-->C), but not in exon 7 (G-->T) or the variable number tandem repeat in intron 4, of the endothelial nitric oxide synthase gene is positively associated with acute coronary syndrome in the Ukrainian population.

@article{Dosenko2006AllelicPI,
  title={Allelic polymorphism in the promoter (T-->C), but not in exon 7 (G-->T) or the variable number tandem repeat in intron 4, of the endothelial nitric oxide synthase gene is positively associated with acute coronary syndrome in the Ukrainian population.},
  author={Victor E. Dosenko and Vyacheslav Yu Zagoriy and Yaroslav M Lutay and Alexandr N Parkhomenko and Alexey A Moibenko},
  journal={Experimental and clinical cardiology},
  year={2006},
  volume={11 1},
  pages={11-3}
}
BACKGROUND Different allelic variants of endothelial nitric oxide synthase (eNOS) can have different effects on the development of certain forms of ischemic heart disease, depending on the specific human population. The frequency of the polymorphism T(-786) --> C in the promoter, G(894)-->T in exon 7 and the variable number tandem repeat in intron 4 were assayed in patients with acute coronary syndrome compared with clinically healthy individuals in the Ukrainian population. METHODS… CONTINUE READING