Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.

@article{Fidock2000AllelicMO,
  title={Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.},
  author={David A. Fidock and Takashi Nomura and Roland Arthur Cooper and Xin-zhuan Su and A K Talley and Thomas E Wellems},
  journal={Molecular and biochemical parasitology},
  year={2000},
  volume={110 1},
  pages={1-10}
}
The determinant of chloroquine resistance (CQR) in a Plasmodium falciparum cross was previously mapped by linkage analysis to a 36 kb segment of chromosome 7. Candidate genes within this segment have been previously shown to include two genes, cg2 and cg1, that have complex polymorphisms linked to the CQR phenotype. Using DNA transfection and allelic exchange, we have replaced these polymorphisms in CQR parasites with cg2 and cg1 sequences from chloroquine sensitive parasites. Drug assays of… CONTINUE READING

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