Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

@article{EmmertBuck1995AllelicLO,
  title={Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.},
  author={Michael R. Emmert-Buck and Cathy D. Vocke and Rudy O. Pozzatti and Paul H. Duray and S. M. Jennings and Charles Florence and Zhengping Zhuang and David G. Bostwick and Lance A. Liotta and W. Marston Linehan},
  journal={Cancer research},
  year={1995},
  volume={55 14},
  pages={2959-62}
}
The development and progression of human prostate cancer is associated with genetic abnormalities in tumor cells. Inactivation of tumor suppressor genes due to allelic loss is thought to be an important mechanism of gene alteration in prostatic neoplasms. In this study we examined allelic loss on chromosome 8p12-21 in microdissected samples of normal prostatic epithelium, high grade prostatic intraepithelial neoplasia (PIN), and invasive prostate carcinoma from the same patients. Tissue… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 105 extracted citations

Similar Papers

Loading similar papers…