Allelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas

@article{Ward2001AllelicLO,
  title={Allelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas},
  author={Bryan K Ward and Premlata Kumar and Gavin R. Turbett and Joanne Edmondston and John M. Papadimitriou and Nigel G Laing and David M. Ingram and Rodney F. Minchin and Thomas Ratajczak},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2001},
  volume={127},
  pages={109-115}
}
Purpose: Cyclophilin 40 (CyP40) is an estrogen receptor-associated protein which appears to modify receptor function. The aim of this study was to determine the extent of allelic loss at the CyP40 locus in a panel of breast carcinomas using a newly characterized microsatellite marker located upstream of the CyP40 gene and then to correlate this with losses at chromosomal sites for cancer-associated genes. Methods: Allelic loss at CyP40 was determined from patients' matched tumor and normal… CONTINUE READING

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