Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma.


OBJECTIVES Previous work has suggested that prostatic intraepithelial neoplasia (PIN) may be a premalignant lesion important in tumorigenesis of the prostate. However, to adequately test this hypothesis at the genetic level, it is necessary to determine whether lesions in close proximity demonstrate similar genetic alterations and, hence, whether an… (More)


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