Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions.

@article{Henske1996AllelicLI,
  title={Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions.},
  author={Elizabeth P Henske and Bernd Walter Scheithauer and M. Priscilla Short and Robert W Wollmann and J. Nahmias and Nick Hornigold and M van Slegtenhorst and Cynthia T. Welsh and David J Kwiatkowski},
  journal={American journal of human genetics},
  year={1996},
  volume={59 2},
  pages={400-6}
}
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by seizures, mental retardation, and hamartomatous lesions. Although hamartomas can occur in almost any organ, they are most common in the brain, kidney, heart, and skin. Allelic loss or loss of heterozygosity (LOH) in TSC lesions has previously been reported on chromosomes 16p13 and 9q34, the locations of the TSC2 and TSC1 genes, respectively, suggesting that the TSC genes act as tumor-suppressor genes. In our study, 87… CONTINUE READING

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