Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas.

@article{Pinto1999AllelicLI,
  title={Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas.},
  author={Andr{\'e}a Pereira Pinto and Marie C.M. Lin and George L. Mutter and Dai-zhen Sun and Luisa L. Villa and Christopher P Crum},
  journal={The American journal of pathology},
  year={1999},
  volume={154 4},
  pages={
          1009-15
        }
}
Vulvar squamous cell carcinoma (VSCC) is a biologically and morphologically diverse disease, consisting of human papillomavirus (HPV)-positive and -negative tumors that differ in their morphological phenotypes and associated vulvar mucosal disorders. This study analyzed the frequencies of allelic loss (loss of heterozygosity (LOH)) in HPV-positive and -negative VSCCs to identify potential targets for the study of preinvasive diseases, to determine whether HPV status influenced patterns of LOH… CONTINUE READING

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