Allelic loss and prognosis in carcinoma of the uterine cervix.

  title={Allelic loss and prognosis in carcinoma of the uterine cervix.},
  author={A. M. Kersemaekers and Gemma G Kenter and J E Hermans and Gert Jan J Fleuren and Marc Joan Van de Vijver},
  journal={International journal of cancer},
  volume={79 4},
Cervical carcinomas develop as a result of multiple genetic alterations. As the genetic alterations are the cause of malignant transformation, it is likely that specific genetic alterations lead to specific clinical behaviour. The aim of this study was (i) to localise chromosome arms that harbour likely tumour-suppressor genes, by analysing loss of heterozygosity (LOH) and (ii) to study the association of LOH with clinicopathological parameters. To define the regions of interest, we studied the… CONTINUE READING


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