Allelic imbalances in human bladder cancer: genome-wide detection with high-density single-nucleotide polymorphism arrays.

@article{Primdahl2002AllelicII,
  title={Allelic imbalances in human bladder cancer: genome-wide detection with high-density single-nucleotide polymorphism arrays.},
  author={Hanne Primdahl and Friedrik Wikman and Hans von der Maase and Xiao-ge Zhou and Hans Julius Wolf and Torben Falck Orntoft},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 3},
  pages={
          216-23
        }
}
BACKGROUND Bladder cancer is characterized by genomic instability. In this study, we investigated whether genome-wide screening using single-nucleotide polymorphism (SNP) arrays could detect allelic imbalance (loss or gain of at least one allele) in bladder cancers. METHODS For microarray analysis, DNA was isolated from microdissected bladder tumors and leukocytes from 11 patients. The stage T1 tumor (connective tissue invasive) and the subsequent stage T2-4 tumor (muscle invasive) were… CONTINUE READING

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