Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

@inproceedings{Milani2007AllelicII,
  title={Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells},
  author={Lili Milani and Manu Gupta and Malin C. Andersen and Sumeer Dhar and M{\aa}rten Frykn{\"a}s and Anders Isaksson and Rolf Larsson and Ann-Christine Syv{\"a}nen},
  booktitle={Nucleic acids research},
  year={2007}
}
Using the relative expression levels of two SNP alleles of a gene in the same sample is an effective approach for identifying cis-acting regulatory SNPs (rSNPs). In the current study, we established a process for systematic screening for cis-acting rSNPs using experimental detection of AI as an initial approach. We selected 160 expressed candidate genes that are involved in cancer and anticancer drug resistance for analysis of AI in a panel of cell lines that represent different types of… CONTINUE READING

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