Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.

@article{Dunsmuir1998AllelicII,
  title={Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.},
  author={William D Dunsmuir and Stephen M Edwards and Sunil R Lakhani and M. Young and Cathy Corbishley and Roger Sinclair Kirby and David Paul Dearnaley and Anna Dowe and Audrey T Ardern-Jones and Jacinta Kelly and Rosalind A. Eeles},
  journal={British Journal of Cancer},
  year={1998},
  volume={78},
  pages={1430 - 1433}
}
A recent report has provided strong evidence for a major prostate cancer susceptibility locus (HPC1) on chromosome 1q24-25 (Smith et al, 1996). Most inherited cancer susceptibility genes function as tumour-suppressor genes (TSGs). Allelic loss or imbalance in tumour tissue is often the hallmark of a TSG. Studies of allelic loss have not previously… CONTINUE READING