Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.

  title={Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.},
  author={Nicholas J. Bray and Luke Jehu and Valentina Moskvina and Joseph D. Buxbaum and Stella Dracheva and Vahram Haroutunian and Julie Williams and Paul R. Buckland and Michael J Owen and Michael C O'Donovan},
  journal={Human molecular genetics},
  volume={13 22},
The epsilon4 haplotype of APOE is the only undisputed genetic risk factor for late-onset Alzheimer's disease (LOAD). It has been proposed that at least two other polymorphisms in the promoter of the APOE gene (-219G>T and -491A>T) might also contribute to disease susceptibility, and modulate the impact of structural changes in the ApoE protein, by altering its expression. In order to assess the extent of cis-acting influences on APOE expression in human brain, highly quantitative measures of… CONTINUE READING


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