Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

@article{Hirota2004AllelicEI,
  title={Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.},
  author={Takeshi Hirota and Ichiro Ieiri and Hiroshi Takane and Shinji Maegawa and Masakiyo Hosokawa and Kaoru Kobayashi and Kan Chiba and Eiji Nanba and Mitsuo Oshimura and Tetsuo Sato and Shun Higuchi and Kenji Otsubo},
  journal={Human molecular genetics},
  year={2004},
  volume={13 23},
  pages={2959-69}
}
The human cytochrome P450 3A4 (CYP3A4) plays a dominant role in the metabolism of numerous clinically useful drugs. Alterations in the activity or expression of this enzyme may account for a major part of the variation in drug responsiveness and toxicity. However, it is generally accepted that most of the known single nucleotide polymorphisms in the coding and 5'-flanking regions are not the main determinants for the large inter-individual variability of CYP3A4 expression and activity. We show… CONTINUE READING

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