Allelic exclusion of alpha chains in TCRs.

  title={Allelic exclusion of alpha chains in TCRs.},
  author={Don W. Mason},
  journal={International immunology},
  volume={6 6},
Although the beta chains of alpha beta+ T cells exhibit allelic exclusion it has recently been shown that approximately 20-30% of such cells express both alpha chain alleles on their surface. Potentially these cells have dual specificity, and it has been suggested that they may play a role in autoimmunity and alloreactivity. The analysis presented in this paper examines critically the possibility that the observed violation of allelic exclusion of alpha chain expression arises as a natural… CONTINUE READING

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