Allelic exclusion of alpha chains in TCRs.

@article{Mason1994AllelicEO,
  title={Allelic exclusion of alpha chains in TCRs.},
  author={Don W. Mason},
  journal={International immunology},
  year={1994},
  volume={6 6},
  pages={881-5}
}
Although the beta chains of alpha beta+ T cells exhibit allelic exclusion it has recently been shown that approximately 20-30% of such cells express both alpha chain alleles on their surface. Potentially these cells have dual specificity, and it has been suggested that they may play a role in autoimmunity and alloreactivity. The analysis presented in this paper examines critically the possibility that the observed violation of allelic exclusion of alpha chain expression arises as a natural… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…