Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein.

@article{Corcos1991AllelicEI,
  title={Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein.},
  author={Daniel Corcos and Antonio Iglesias and Olga Dunda and Danielle Bucchini and Jacques Jami},
  journal={European journal of immunology},
  year={1991},
  volume={21 11},
  pages={2711-6}
}
Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proliferate in vivo although they cannot bind any antigen, due to deletions in the variable domain of their antigen receptors. The reason for the clonal proliferation of HCD cells and the biological effects of the… CONTINUE READING

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