Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium

  title={Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium},
  author={Thomas Sander and Helmut Harms and Jan Podschus and Ulrich Finckh and Bernd Nickel and Arndt Rolfs and Hans Rommelspacher and Lutz G. Schmidt},
  journal={Biological Psychiatry},

Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population

The present findings suggest that DAT1 genetic variation influences drinking behavior in the Finnish population, where the rs6350 A and rs463379 G alleles provide a protective role against high alcohol consumption and alcohol dependence, respectively.

Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review.

A systematic review of studies examining associations between polymorphisms in DAT1 and alcohol dependence found several, but not all, studies found that the Dat1 variable number tandem repeat (9-repeat allele) was associated with alcohol-withdrawal symptoms, such as seizures and delirium tremens.

[Combination of DAT and DBH gene polymorphisms with a family history of alcohol use disorders increases the risk of withdrawal seizures and delirium tremens during alcohol withdrawal in alcohol-dependent men].

This study demonstrates the genetic influence of a family history of alcohol use disorders and DAT and DBH gene polymorphisms on the risk of withdrawal seizures and delirium tremens and the interaction of genetic variations with the age at first alcohol use may protect carriers from negative influence of this «behavioral» risk factor.

The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence.

Evidence is added for a significant role of the 3' part of the DAT1 gene in WS of alcohol-dependent patients not only because it is in accordance with previous work, but also because of larger statistical power (as relying on a sample over sampled with the studied phenotype).

Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics

Haplotype analysis, sub-grouping with respect to more homogeneous endophenotypes, and inclusion of quantifiable characteristics are sensible strategies to untangle the genetic background of such a complex disorder like alcohol dependence.

Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence

Genetic constitution interacts with the in vivo availability of central dopamine and serotonin transporters during alcohol detoxification and may affect the severity of alcohol withdrawal and clinical depression.



Dopamine transporter gene polymorphism and alcoholism.

The frequency of the 7-repeat allele of the DAT1 variable number of tandem repeat was significantly higher in alcoholics with ALDH2*2 than in control subjects, consistent with the hypothesis that alteration in the dopaminergic system plays some role in the development of alcoholism.

Association of attention-deficit disorder and the dopamine transporter gene.

Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed a

The D2 dopamine receptor gene: A review of association studies in alcoholism

It is suggested that theDRD2 gene is the most prominent single gene determinant of susceptibility to severe substance abuse, and the larger role still appears to be played by a combination of environmental factors and as yet unidentified genes.

Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis.

Overall, the meta-analysis of the results from all 8 studies supported a statistically significant association between the A1 allele of DRD2 and alcoholism, with an apparent increase in relative risk associated with increased severity of alcoholism.

Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics

The results indicate that both types of alcoholics have alterations in striatal dopaminergic system, though these occur in opposite directions.

Population genetic study of the human dopamine transporter gene (DAT1)

It is shown that screening a large population identifies new alleles and generates more accurate allele frequencies and a previously unreported allele was detected in all three populations.

DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations.

The existence of large interpopulation differences in the frequency of the Taq1 alleles suggests that associations to disease status could readily be generated or masked if disease and control groups were uneven in ethnic composition.

Neurogenetic adaptive mechanisms in alcoholism.

Three dimensions of personality have been described that may reflect individual differences in brain systems modulating the activation, maintenance, and inhibition of behavioral responses to the effects of alcohol and other environmental stimuli that distinguish alcoholics with different patterns of behavioral, neurophysiological, and neuropharmacological responses to alcohol.

The genetic epidemiology of alcoholism

One major focus of current research on possible central nervous system (CNS) mechanisms for the effect of alcohol includes assessment of the role of alcohol in the stimulation of brain reward or reinforcement systems.