Allelic Loss on Chromosome 17 in Ductal Carcinoma

Abstract

Multiple tumor suppressor genes are implicated in the oncogenesis and progression of invasive carcinoma of the breast. To investigate the chro nology of genetic changes we studied loss of heterozygosity on chromo some 17 in ductal carcinoma in situ, a preinvasive breast cancer. A microdissection technique was used to separate tumor from normal stromal cells… (More)

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