Allelic Frequency of p53 Gene Codon 72 Polymorphism in Urologic Cancers

  title={Allelic Frequency of p53 Gene Codon 72 Polymorphism in Urologic Cancers},
  author={Wen‐Jeng Wu and Yoshiyuki Kakehi and Tomonori Habuchi and Hidefumi Kinoshita and Osamu Ogawa and Toshiro Terachi and C J Huang and Chin‐Pei Chiang and Osamu Yoshida},
  booktitle={Japanese journal of cancer research : Gann},
Alterations in the p53 tumor suppressor gene appear to be important in the development of many human tumors. The wild-type p53 gene has a polymorphism at codon 72 that presents the arginine (CGC) or proline (CCC) genotype, which recently has been reported to be associated with genetically determined susceptibility to smoking-related lung cancers. To determine whether this p53 genotype influences individual risk of urologic cancer and/or its progression, we used polymerase chain reaction… CONTINUE READING
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