Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

@inproceedings{Roxburgh2009AllelicDO,
  title={Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease},
  author={Sarah A. Roxburgh and Jayesh J. Kattla and Simon P. Curran and Yvonne M. O'Meara and Carol A. Pollock and Roel Goldschmeding and Catherine G. Godson and Finian M Martin and Derek P. Brazil},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Gremlin (grem1) is an antagonist of the bone morphogenetic protein family that plays a key role in limb bud development and kidney formation. There is a growing appreciation that altered grem1 expression may regulate the homeostatic constraints on damage responses in diseases such as diabetic nephropathy. RESEARCH DESIGN AND METHODS Here we explored whether knockout mice heterozygous for grem1 gene deletion (grem1(+/-)) exhibit protection from the progression of diabetic kidney… CONTINUE READING

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