Alleles that modulate late life hearing in genetically heterogeneous mice.

  title={Alleles that modulate late life hearing in genetically heterogeneous mice.},
  author={Jochen Schacht and Richard A. Altschuler and David T. Burke and Shu Chen and David W. P. Dolan and Andrzej T. Galecki and David C Kohrman and Richard L. Miller},
  journal={Neurobiology of aging},
  volume={33 8},
A genetically heterogeneous population of mice was tested for hearing at 8, 18, and 22 months by auditory brainstem response (ABR), and genotyped at 128 markers to identify loci that modulate late life hearing loss. Half of the test mice were exposed to noise for 2 hours at age 20 months. Polymorphisms affecting hearing at 18 months were noted on chromosomes 2, 3, 7, 10, and 15. Most of these loci had effects only on responses to 48 kHz stimuli, but a subset also influenced the auditory… CONTINUE READING
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