Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ F T cell clones

Abstract

T cells recognize peptide and non-peptide antigens. Drugs represent typical examples of nonpeptide antigens. The majority of drug-specific T cells are αβF TCR T cells and are MHC class I or II restricted. Here we show the existence of drug (lidocaine)-specific T cell clones which proliferate in the presence of antigen-presenting cells (APC) with different… (More)

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