Allele-specific targeting of microRNAs to HLA-G and risk of asthma.

  title={Allele-specific targeting of microRNAs to HLA-G and risk of asthma.},
  author={Zheng Tan and Glenn Randall and Jihua Fan and Blanca Camoretti-Mercado and Rebecca A. Brockman-Schneider and Lin Pan and Julian Solway and James E Gern and Robert F. Lemanske and Dan L. Nicolae and Carole Ober},
  journal={American journal of human genetics},
  volume={81 4},
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at… CONTINUE READING
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