Allele-specific replication timing of imprinted gene regions

@article{Kitsberg1993AllelespecificRT,
  title={Allele-specific replication timing of imprinted gene regions},
  author={Daniel Kitsberg and Sara M. Selig and M. Brandels and Itamar Simon and Ilana Keshet and Daniel J. Driscoll and Robert D. Nicholls and Howard Cedar},
  journal={Nature},
  year={1993},
  volume={364},
  pages={459-463}
}
SEVERAL lines of evidence suggest that the paternal and maternal genomes may have different expression patterns in the developing organism1 and this has been confirmed by the identification of endogenous genes that are parentally imprinted in the mouse2–5. Little is known about the precise mechanisms involved in the process, but structural differences between the two alleles must somehow provide cis-acting signals for directing parental-specific transcription. Cell-cycle replication time is one… CONTINUE READING

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