Allele-specific regulation of TCR beta variable gene segment chromatin structure.

@article{Jackson2005AllelespecificRO,
  title={Allele-specific regulation of TCR beta variable gene segment chromatin structure.},
  author={Annette M. Jackson and Michael S Krangel},
  journal={Journal of immunology},
  year={2005},
  volume={175 8},
  pages={5186-91}
}
Allelic exclusion of the murine Tcrb locus is imposed at the level of recombination and restricts each cell to produce one functional VDJbeta rearrangement. Allelic exclusion is achieved through asynchronous Vbeta to DJbeta recombination as well as feedback inhibition that terminates recombination once a functional rearrangement has occurred. Because the accessibility of Vbeta gene segment chromatin is diminished as thymocytes undergo allelic exclusion at the CD4(-)CD8(-) (double-negative) to… CONTINUE READING