Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.

@article{Eriksson1995AllelespecificII,
  title={Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.},
  author={Per Eriksson and B Kallin and F M van 't Hooft and Peter N B{\aa}venholm and Anders Hamsten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 6},
  pages={1851-5}
}
Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is significantly higher in patients with myocardial infarction before the age of 45 than in… CONTINUE READING