Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain.

@article{Carr2007AllelespecificHM,
  title={Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain.},
  author={Michael S. Carr and Aleksey Yevtodiyenko and Claudia L. Schmidt and Jennifer V Schmidt},
  journal={Genomics},
  year={2007},
  volume={89 2},
  pages={280-90}
}
Dlk1 and Gtl2 are reciprocally expressed imprinted genes located on mouse chromosome 12. The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are methylated only on the paternal allele. Of these, the intergenic (IG) DMR, located 12 kb upstream of Gtl2, is required for proper imprinting of linked genes on the maternal chromosome, while the Gtl2 DMR, located across the promoter of the Gtl2 gene, is implicated in imprinting on both parental chromosomes. In addition to… CONTINUE READING